Cut sutures? Too long or too short!

The QT interval: too long, too short or just right.

Is the travel time of private roads too short , too long , or just right ? †

We consider price and service-quality setting in oligopolistic markets for congestible services, applied to the case of private roads. Previous studies show that parallel competitors set a volume/capacity ratio (and thereby a travel time or service quality) that is socially optimal if they take the actions of the others as given. We find that this result does not hold when capacity and toll set...

Too Long, Too Short, or Just Right: Glycosphingolipid–Protein Binding Varies with Acyl Chain Length

The history of life is fi lled with examples of one species diverging into several, even thousands, each with unique traits geared to the demands of its ecological niche. In the textbook case of adaptive radiation, an ancestral fi nch species landed on the Galapagos Islands just a few million years ago, and evolved into 13 new species with specialized beaks adapted to exploiting the various see...

Don't cut too soon

JCB • VOLUME 173 • NUMBER 3 • 2006 316 C aren Norden, Manuel Mendoza, Yves Barral (ETH, Zurich, Switzerland), and colleagues have found a new checkpoint in yeast cell division. Cytokinesis, they show, is delayed until chromosomes are out of the way, thanks to a pathway that monitors the spindle midzone. If cytokinesis were to occur too soon, chromatids still lingering in the spindle midzone mig...

Too much or too little

The global effort to understand the molecular drivers of cancer onset and progression is now coming to fruition with the identification of specific genomic and epigenomic events that influence signaling through key oncogenic pathways. Genetic studies using inducible expression of the critical growth controlling oncogenes MYC, RAS, PI3K and AKT have shown unequivocally that, in conjunction with ...